Perioperative medicine & outcomes
Effect of cardiac-index guided intraoperative haemodynamic therapy on postoperative outcome in non-cardiac surgery patients – a systematic review and meta-analysis
Pooled result · Postoperative complicationsResult — go to the resultOdds ratio .59 95% CI .45-.78Authors' conclusion
CI-GDT was associated with a lower incidence of patients experiencing at least one postoperative complication, whereas mortality did not differ significantly. However, substantial heterogeneity and a prediction interval crossing the null indicate that the benefit may not be consistent across clinical settings. These findings do not establish an independent advantage of CI targeting over other GDT strategies.
Study context
- Population
- Adult non-cardiac surgery patients in randomised controlled trials comparing CI-GDT to standard careRandomised controlled trials (RCTs) included, 20 contributed data to the meta-analysis of postoperative complications
- Participants
- 21 patients
- Comparison
- CI-GDT compared to standard care
- Outcome
- Postoperative complications
Methodological detailsrandom-effects model, PRISMA guidelines, RoB 2 tool, leave-one-out analysis
- Random-effects model
- PRISMA guidelines
- RoB 2 tool
- Leave-one-out analysis
Pooled result
As reported in the abstract
Odds ratio
.59
95% CI .45-.78
CI-GDTvs standard care
OR .59 (95% CI .45-.78)
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| MortalityI2 = 0%; did not differ significantly | 0.77 (.57-1.05) | |
| 0.512Odds ratio (log scale) |
Publication bias
- Funnel plot and Egger's test indicated no significant publication bias
- P = 0.15
- Trim-and-fill did not suggest missing studies
Sensitivity (leave-one-out analysis)
- Leave-one-out analysis confirmed robustness of findings
Certainty of evidence
- Certainty of evidence was graded high
Original publication
Effect of cardiac-index guided intraoperative haemodynamic therapy on postoperative outcome in non-cardiac surgery patients – a systematic review and meta-analysis. Perioper Med (Lond). Published 7 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →