Effect of Combination of Subcutaneous Lidocaine With Two Different Doses of Nitroglycerin Versus Subcutaneous Lidocaine Alone for Ultrasound-guided Radial Artery Cannulation: A Randomized Controlled Trial
Primary result · First-attempt success rateResult — go to the resultChi-square 12.61Authors' conclusion
Subcutaneous infiltration of nitroglycerin before cannulation improved the first-attempt success rate in adult patients and a comparable overall attempt success rate was obtained even with lower doses of nitroglycerin.
Study context
- Population
- Adults aged 18 to 70 years, ASA I–III, undergoing ultrasound-guided radial artery cannulation, tertiary care hospital
- Comparison
- Subcutaneous lidocaine + nitroglycerin 250 μg or 500 μg vs lidocaine + normal saline
Methodological detailsdouble-blinded, single-centre
- Double-blinded
- Single-centre
Primary result
First-attempt success rate
Chi-square
12.61
P = 0.002
By group
As reported in the abstract
Further findings
Mean, mm²
| Outcome | C | T1 | T2 | Analysis of variance F | P value |
|---|---|---|---|---|---|
| Increase in radial artery CSA · 5 minutes after administrationT1 and T2 vs C | 1.33 (SD 3.93) | 5.81 (SD 4.69) | 7.13 (SD 4.41) | 25.4 | P < 0.001 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of Combination of Subcutaneous Lidocaine With Two Different Doses of Nitroglycerin Versus Subcutaneous Lidocaine Alone for Ultrasound-guided Radial Artery Cannulation: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 6 June 2025. doi:10.
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