Cardiothoracic & vascular anesthesia
The effect of continuous bilateral parasternal block with lidocaine on patient-controlled analgesia opioid requirement and recovery after open heart surgery: a double-blind randomised controlled trial
Authors' conclusion
After sternotomy for open heart surgery, a 72-h bilateral parasternal lidocaine infusion significantly decreased PCA and total morphine requirement. However, neither signs of decreased inflammatory response nor an improvement in recovery was seen.
Study context
- Population
- Patients undergoing sternotomy for open heart surgery
- Participants
- 45 patients
- Comparison
- 72-h bilateral parasternal lidocaine vs saline infusion
- Primary endpoint
- Cumulative PCA morphine consumption
- Follow-up
- 72 h
Methodological detailsdouble-blind
- Double-blind
Primary result
As reported in the abstract
P = 0.014
Secondary outcomes
Total morphine requirement (incl. morphine before patient-controlled analgesia (PCA)) · 24, 48, and 72 h
- Significantly lower with lidocaine at 24, 48, and 72 h
Pain scores
- Pain well controlled; no difference between groups
Peak expiratory flow · 72 h
- Lower in the lidocaine group at 72 h
Interleukin-6 concentration · 24, 48, or 72 h
- No difference at 24, 48, or 72 h
QoR-15 scores · 3-month follow-up
- No difference between groups at any time during 3-month follow-up
Original publication
The effect of continuous bilateral parasternal block with lidocaine on patient-controlled analgesia opioid requirement and recovery after open heart surgery: a double-blind randomised controlled trial. BJA Open. Published 20 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →