Perioperative medicine & outcomes
Effect of driving pressure-guided positive end-expiratory pressure on postoperative pulmonary complications in patients undergoing laparoscopic or robotic surgery: a randomised controlled trial
Primary resultResult — go to the resultRelative risk 0.72 95% CI 0.45–1.15Authors' conclusion
Driving pressure-guided PEEP did not decrease the incidence of pulmonary complications within 7 days of laparoscopic or robotic lower abdominal surgery, although uncertainty remains given the lower than anticipated event rate for the primary outcome.
Study context
- Population
- Patients at risk for postoperative pulmonary complications (PPCs) undergoing laparoscopic or robotic lower abdominal surgeryrandomised
- Participants
- 384 patients
- Comparison
- Driving pressure-guided positive end-expiratory pressure (PEEP) vs 5 cm H2O fixed PEEP during surgery
- Individualised PEEPn = 178
- Standard PEEPn = 185reference
- Primary endpoint
- Composite of pulmonary complications (pre-specified clinical and radiological criteria), analysed per protocol
- Follow-up
- Within 7 postoperative days
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Relative risk
0.72
95% CI 0.45–1.15
P = 0.215
Events by treatment group
Individualised PEEP vs Standard PEEP
RR 0.72 (95% CI 0.45–1.15); P = 0.215
Further findings
Mean, cm H2O
| Outcome | Individualised PEEP | Standard PEEP | Mean difference (cm H2O) (95% CI) | P value | |
|---|---|---|---|---|---|
| Driving pressure | 14.7 (SD 2.6) | 18.4 (SD 3.2) | −3.7 (−4.3 to −3.1) | P < 0.001 | |
| −6−4−202Difference, cm H2O (linear scale) |
| Outcome | Individualised PEEP | Standard PEEP | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Pulmonary complications due to desaturation | 4.5% | 16.2% | 0.28 (0.13–0.59) | P = 0.001 | |
| 0.10.31310Relative risk (log scale) |
| Outcome | Individualised PEEP | Standard PEEP |
|---|---|---|
| Applied PEEP | mean 13.6 (SD 2.1) cm H2O | — not stated in the abstract |
— not stated in the abstract
Original publication
Effect of driving pressure-guided positive end-expiratory pressure on postoperative pulmonary complications in patients undergoing laparoscopic or robotic surgery: a randomised controlled trial. Br J Anaesth. Published 9 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →