The effect of magnesium sulfate on emergence agitation in surgical adult patients undergoing general anesthesia: A systematic review and meta-analysis of randomized controlled trials
Authors' conclusion
Limited available evidence suggests that MS was associated with a lower incidence of EA.
Study context
- Population
- Adults undergoing surgery under general anesthesia (GA)5 randomized controlled trials (RCTs)
- Comparison
- Intravenous magnesium sulfate vs control
- Outcome
- Incidence of emergence agitation (EA)
Pooled result
As reported in the abstract
Incidence of EA
MSRelative risk (95% CI)
0 min; p = 0.183, I2 = 43.6%
0.62([0.41, 0.95])
5 min; p = 0.211, I2 = 36%
0.29([0.16, 0.52])
10 min; p = 0.449, I2 = 0%
0.14([0.06, 0.32])
15 min; p = 0.265, I2 = 19.5%
0.11([0.02, 0.55])
Postoperative period; p = 0.724, I2 = 0%
0.21([0.09, 0.49])
- 30 min
- RR 0.05 (95% CI [0.00, 0.91])
Further pooled results
Postoperative agitation score (PAS)
- Magnesium sulfate (MS) associated with reduced PAS at various time points except 0 min
Extubation time, PACU LOS
- No significant differences
Safety
PONV and total complications
- No significant differences
Original publication
The effect of magnesium sulfate on emergence agitation in surgical adult patients undergoing general anesthesia: A systematic review and meta-analysis of randomized controlled trials. J Clin Anesth. Published 14 May 2024. doi:10.
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