Respiratory failure & ventilation
Effect of mechanical power on mortality in invasively ventilated ICU patients without the acute respiratory distress syndrome: An analysis of three randomised clinical trials
Authors' conclusion
In ICU patients receiving invasive ventilation for reasons other than ARDS, MP had an independent association with mortality.
Study context
- Population
- Invasively ventilated ICU patients without acute respiratory distress syndrome (ARDS), academic and nonacademic ICUs in the Netherlands706 (36%) women
- Participants
- 1,962 participants
- Comparison
- Increasing mechanical power levels
- Outcome
- All-cause mortality
- Follow-up
- Day 28
Pooled result
As reported in the abstract
- Died at day 28
- 644 patients (33%)
- Hazard ratios for mortality higher with increasing mechanical power (MP), even when stratified for driving pressure
- P < 0.001
- Higher with increasing MP, stratified for tidal volume
- P < 0.001
- Higher with increasing MP, stratified for respiratory rate
- P < 0.001
- Higher with increasing MP, stratified for maximum airway pressure
- P = 0.001
Further pooled results
Mortality at day 90, ICU and hospital LOS
- Similar associations of MP found
Original publication
Effect of mechanical power on mortality in invasively ventilated ICU patients without the acute respiratory distress syndrome: An analysis of three randomised clinical trials. Eur J Anaesthesiol. Published 18 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →