Respiratory failure & ventilation
Association of ventilation volumes, pressures and rates with the mechanical power of ventilation in patients without acute respiratory distress syndrome: exploring the impact of rate reduction
Authors' conclusion
In this cohort of patients without acute respiratory distress syndrome, pressure and respiratory rate were the most important determinants of mechanical power.
Study context
- Population
- Invasively ventilated patients without ARDS
- Participants
- 1,732 participants · 3 RCTs
- Outcome
- Mechanical power
Methodological detailslinear regression, double stratification, mediation analysis
- Linear regression
- Double stratification
- Mediation analysis
Pooled result
As reported in the abstract
Mechanical power and its determinants
- Mechanical power, median (IQR [range]), J.min-1
- 12.3 (9.3-17.1 [3.7-50.1])
- Share of increase in mechanical power explained by respiratory rate (linear regression)
- 36%
- Share of increase in mechanical power explained by peak pressure (linear regression)
- 51%
- Increasing quintiles of peak pressure at constant respiratory rate: RR of high mechanical power 2.2 (95% CI 1.8-2.6)
- p < 0.01
- Decreasing quintiles of respiratory rate at constant peak pressure: RR of high mechanical power 0.2 (95% CI 0.2-0.3)
- p < 0.01
- Mediation: reduction in respiratory rate with increased tidal volume, average causal mediation effect −0.10 (95% CI −0.12 to −0.09)
- p < 0.01
- Direct effect of tidal volume on mechanical power, average direct effect 0.15 (95% CI 0.11-0.19)
- p < 0.01
Original publication
Association of ventilation volumes, pressures and rates with the mechanical power of ventilation in patients without acute respiratory distress syndrome: exploring the impact of rate reduction. Anaesthesia. Published 13 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →