Respiratory failure & ventilation
Sigh Ventilation in Patients With Trauma: The SiVent Randomized Clinical Trial
Authors' conclusion
In a pragmatic, randomized trial among trauma patients receiving mechanical ventilation with risk factors for developing acute respiratory distress syndrome, the addition of sigh breaths did not significantly increase ventilator-free days.
Study context
- Population
- Adult trauma patients mechanically ventilated <24 hours with ≥1 of 5 ARDS risk factors, expected ventilation >24 hours; 15 US academic trauma centers, 2016–20225,753 screened
- Participants
- 524 participants
- Comparison
- Sigh breaths plus usual care vs usual care alone
- Primary endpoint
- Ventilator-free days
Methodological detailspragmatic, multicentre
- Pragmatic
- Multicentre
Primary result
As reported in the abstract
Sighs
18.4
median · IQR 7.0–25.2
Usual care
16.1
median · IQR 1.1–24.4
Secondary outcomes
All-cause 28-day mortality · prespecified secondary outcome
P = 0.05
Safety
Nonfatal adverse events
Nonfatal adverse events
- No differences observed
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sigh Ventilation in Patients With Trauma: The SiVent Randomized Clinical Trial. JAMA. Published 28 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →