Respiratory failure & ventilation
Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial
Authors' conclusion
Among critically ill adults who received invasive mechanical ventilation for more than 24 hours, screening frequency (once-daily vs more frequent screening) and SBT technique (pressure-supported vs T-piece SBT) did not change the time to successful extubation. However, an unexpected and statistically significant interaction was identified; protocolized more frequent screening combined with pressure-supported SBTs increased the time to first successful extubation.
Study context
- Population
- Critically ill adults receiving invasive mechanical ventilation for ≥24 hours, able to initiate spontaneous breaths or trigger ventilators, FiO2 ≤70% and PEEP ≤12 cm H2O; 23 ICUs in North America
- Participants
- 797 adults
- Comparison
- More frequent vs once-daily screening, and pressure-supported vs T-piece spontaneous breathing trial (SBT)
- Once-daily screening and pressure-supported SBTn = 198
- Once-daily screening and T-piece SBTn = 204reference
- More frequent screening and pressure-supported SBTn = 195
- More frequent screening and T-piece SBTn = 200
- Primary endpoint
- Time to successful extubation (unsupported spontaneous breathing sustained for ≥48 hours after extubation)
Methodological details2 × 2 factorial, multicentre, Recruitment January 2018 to February 2022; last follow-up October 18, 2022
- 2 × 2 factorial
- Multicentre
- Recruitment January 2018 to February 2022; last follow-up October 18, 2022
Primary result
As reported in the abstract
Time to successful extubation
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial. JAMA. Published 3 December 2024. doi:10.
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