Respiratory failure & ventilation
Effect of noninvasive ventilation on tracheal reintubation among patients with hypoxemic respiratory failure following abdominal surgery: a bayesian post-hoc analysis of the NIVAS trial
Primary result · Day-7 reintubationResult — go to the resultPosterior median OR 0.59 95% CrI 0.37–0.95Authors' conclusion
This Bayesian trial re-analysis indicates that NIV has a high probability of achieving a clinically meaningful reduction in day 7 reintubation, even under pessimistic prior beliefs.
Study context
- Population
- Patients with acute respiratory failure following abdominal surgery
- Participants
- 293 patients
- Comparison
- Noninvasive ventilation (NIV) vs conventional oxygen therapy
- Primary endpoint
- Reintubation
- Follow-up
- Day 7
Methodological detailspost-hoc Bayesian reanalysis, prospectively registered, multicentre
- Post-hoc Bayesian reanalysis
- Prospectively registered
- Multicentre
Primary result
Day-7 reintubation
Posterior median OR
0.59
95% CrI 0.37–0.95
NIV vs Oxygen therapy
posterior median OR 0.59 (95% CrI 0.37–0.95)
As reported in the abstract
- Posterior median OR, pessimistic prior
- 0.64 (95% CrI 0.40 to 1.00)
- Posterior probability NIV superior to oxygen therapy, pessimistic to enthusiastic priors
- 96 to 99%
- Probability of benefit beyond absolute risk reduction (ARR) ≥ 5%
- 77 to 93%
Secondary outcomes
Day-30 mortality
- Posterior median OR, minimally informative prior
- 0.63 (95% CrI 0.32 to 1.31)
- Posterior median OR, skeptical prior
- 0.79 (95% CrI 0.48 to 1.29)
- Probability of NIV superiority
- 82 to 90%
Original publication
Effect of noninvasive ventilation on tracheal reintubation among patients with hypoxemic respiratory failure following abdominal surgery: a bayesian post-hoc analysis of the NIVAS trial. Crit Care. Published 10 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →