Respiratory failure & ventilation
Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial
Primary resultResult — go to the resultAbsolute difference - 25% 95% CI - 49 to - 1%Authors' conclusion
Among patients with obesity and hypoxemic respiratory failure following abdominal surgery, use of NIV compared with standard oxygen therapy reduced the risk of reintubation within 7 days, contrary to patients without obesity.
Study context
- Population
- Patients with obesity and acute hypoxemic respiratory failure within 7 days after abdominal surgeryof 293 trial patients
- Participants
- 76 patients
- Comparison
- Noninvasive ventilation (NIV) via facial mask vs standard oxygen therapy
- NIVn = 42
- Standard oxygen therapyn = 34reference
- Primary endpoint
- Reintubation
- Follow-up
- Within 7 days
Methodological detailsmulticentre, intention-to-treat
- Multicentre
- Intention-to-treat
Primary result
As reported in the abstract
Absolute difference
- 25%
95% CI - 49 to - 1%
P = 0.03
Events by treatment group
Secondary outcomes
Invasive ventilation-free days · day 30
P = 0.02
ICU-acquired pneumonia
P = 0.04
30-day survival
P = 0.08
Reintubation, BMI < 30 kg/m² (subgroup) · within 7 days · no significant difference as reported
P = 0.03
- Reintubation, body mass index (BMI) < 30 kg/m² (subgroup): NIV 36/105, standard oxygen therapy 47/109
Reintubation, BMI < 30 kg/m² (subgroup) · within 7 days
- Interaction test: no statistically significant difference between BMI ≥ 30 and BMI < 30 kg/m² subsets
Original publication
Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial. Intensive Care Med. Published 29 July 2024. doi:10.
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