Perioperative medicine & outcomes
Effect of chamomile intake on blood coagulation tests in healthy volunteers: a randomized, placebo-controlled, crossover trial
Authors' conclusion
Chamomile intake by tea or capsule does not prolong PT.
Study context
- Population
- Healthy volunteersall randomised and completed
- Participants
- 12 volunteers
- Comparison
- Chamomile tea vs Placebo capsule
- Primary endpoint
- Change in prothrombin time (PT) before vs after each intervention
Methodological detailsplacebo-controlled, crossover, 7-day washout between intervention periods; 5 weeks per subject
- Placebo-controlled
- Crossover
- 7-day washout between intervention periods; 5 weeks per subject
Primary result
As reported in the abstract
PT change
Chamomile tea
- 0.2
mean · SD 0.4 · s
Extract capsule
- 0.2
mean · SD 0.4 · s
Placebo capsule
0.1
mean · SD 0.5 · s
P = 0.34
Secondary outcomes
International normalized ratio (INR) change
- INR change 0 s for each intervention (p = 0.07)
Activated partial thromboplastin time (aPTT), thrombin time (TT), reptilase time (RT) and fibrinogen change
- No significant change across interventions: aPTT p = 0.8, TT p = 0.08, RT p = 0.8, fibrinogen p = 0.2
Original publication
Effect of chamomile intake on blood coagulation tests in healthy volunteers: a randomized, placebo-controlled, crossover trial. Perioper Med (Lond). Published 20 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →