Respiratory failure & ventilation
Effect of decreasing PEEP on hyperinflation and collapse in COVID‐19: A computed tomography study
Authors' conclusion
In 20 patients with COVID-19 the net response to decreasing PEEP, as assessed with lung CT, was variable. In approximately half of them it was positive (and possibly beneficial), with a decrease in hyperinflation larger than the increase in collapse.
Study context
- Population
- Mechanically ventilated patients with COVID-19
- Participants
- 20 participants
- Comparison
- PEEP 10 vs 15 cmH2O
- Positiven = 11
- Negativen = 9
- Outcome
- Change in over-aerated (hyperinflation) and non-aerated (collapse) lung volumes on CT when decreasing PEEP from 15 to 10 cmH2O; net response = change in pathologic lung volume
Methodological detailsComputed tomography (CT)-based, within-patient comparison
- CT-based
- Within-patient comparison
Main finding
As reported in the abstract
Net response to decreasing PEEP from 15 to 10 cmH2O (change in over-aerated and non-aerated lung volumes on CT)
| Group | Value | Over-aerated lung volume decrease | Non-aerated lung volume increase |
|---|---|---|---|
| Positive | 55% | 159 (98-186) mL | 58 (31-91) mL |
| Negative | 45% | 46 (18-72) mL | 107 (44-121) mL |
Value
Positive55%
Negative45%
Over-aerated lung volume decrease
Positive159 (98-186) mL
Negative46 (18-72) mL
Non-aerated lung volume increase
Positive58 (31-91) mL
Negative107 (44-121) mL
Further findings
- PaO2:FiO2 in overall population
- 137 (119-162) mmHg
Original publication
Effect of decreasing PEEP on hyperinflation and collapse in COVID‐19: A computed tomography study. Acta Anaesthesiol Scand. Published 29 February 2024. doi:10.
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