Respiratory failure & ventilation
Personalized positive end-expiratory pressure in spontaneously breathing patients with acute respiratory distress syndrome by simultaneous electrical impedance tomography and transpulmonary pressure monitoring: a randomized crossover trial
Authors' conclusion
Personalized PEEP selected using synchronized EIT and transpulmonary pressure monitoring could be associated with reduced dynamic lung stress and metabolic work of breathing in ARDS patients undergoing PSV.
Study context
- Population
- Intubated acute respiratory distress syndrome (ARDS) patients undergoing pressure support ventilation (PSV)crossover
- Participants
- 30 patients
- Comparison
- PEEPEIT-∆PL vs PEEPTABLE
Methodological detailsmulticentre, physiologic study, positive end-expiratory pressure (PEEP) trial well tolerated
- Multicentre
- Physiologic study
- PEEP trial well tolerated
Primary result
As reported in the abstract
Physiologic effects · end of each 20-min step
- Lower dynamic ∆PL with PEEPEIT-∆PL
- P < 0.001
- Lower pressure-time product with PEEPEIT-∆PL (variability among patients)
- P < 0.001
- Decreased respiratory drive and effort with PEEPEIT-∆PL
- P < 0.001
- Improved regional lung mechanics with PEEPEIT-∆PL
- P < 0.05
- Reversed lung collapse with PEEPEIT-∆PL
- P = 0.007
- No increase in overdistension with PEEPEIT-∆PL
- P = 0.695
Further findings
PEEP level · PEEPEIT-∆PL differed from PEEPTABLE in all patients
P = 0.021
Original publication
Personalized positive end-expiratory pressure in spontaneously breathing patients with acute respiratory distress syndrome by simultaneous electrical impedance tomography and transpulmonary pressure monitoring: a randomized crossover trial. Intensive Care Med. Published 11 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →