Cardiothoracic & vascular anesthesia
Effect of Deep Hypothermia (18°C) on Dioxygen Metabolism During Pulmonary Thromboendarterectomy Surgery
Authors' conclusion
There were VO2 and OE decreases of more than half their baseline values at 18°C.
Study context
- Population
- Patients undergoing pulmonary thromboendarterectomyincluded in final analysis
- Participants
- 24 patients
- Exposure
- Normothermia vs cooling to 30°C, 25°C and 18°C
- Outcome
- Indexed VO2
Methodological detailssingle-centre, university teaching hospital
- Single-centre
- University teaching hospital
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | 18°C | P value |
|---|---|---|
| Oxygen extraction (OE)18°C vs 36°C | 9% | P < 0.001 |
| Venoarterial difference of O2 bound to Hb18°C vs normal temperature | median 0.03 (IQR 0.01–0.07) mL of O2/100 mL of blood | P < 0.001 |
| Venoarterial difference in dissolved O218°C vs normal temperature | median 1.09 (IQR 1.03–1.32) mL of O2/100 mL of blood | P = 0.0013 |
- Oxygen extraction (OE): 36°C 18%
- Venoarterial difference of O2 bound to Hb: normal temperature median 2.22 (IQR 1.68–2.58) mL of O2/100 mL of blood
- Venoarterial difference in dissolved O2: normal temperature median 0.78 (IQR 0.66–0.92) mL of O2/100 mL of blood
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of Deep Hypothermia (18°C) on Dioxygen Metabolism During Pulmonary Thromboendarterectomy Surgery. J Cardiothorac Vasc Anesth. Published 19 September 2024. doi:10.
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