Effect of dexamethasone and lidocaine combination on incidence of post-operative sore throat: A meta-analysis and trial sequential analysis
Pooled result · POST incidenceResult — go to the resultRelative risk 0.53 95 % CI 0.37–0.75Authors' conclusion
The dexamethasone-lidocaine combination suggests a clinically meaningful reduction in POST compared to dexamethasone alone, with consistent effects across studies.
Study context
- Population
- Patients undergoing endotracheal intubation3 RCTs
- Comparison
- IV dexamethasone-lidocaine combination vs dexamethasone alone
- Outcome
- Incidence of postoperative sore throat (POST)
Methodological detailsrandom-effects model (Mantel-Haenszel), trial sequential analysis, GRADE assessment
- Random-effects model (Mantel-Haenszel)
- Trial sequential analysis
- GRADE assessment
Pooled result
POST incidence
Relative risk
0.53
95 % CI 0.37–0.75
P = 0.0003
Dexamethasone-lidocaine vs Dexamethasone alone
RR 0.53 (95 % CI 0.37–0.75); P = 0.0003
As reported in the abstract
Further pooled results
| Outcome | RR (95 % CI) | P value | |
|---|---|---|---|
| Postoperative coughI2 = 24 % | 0.81 (0.41–1.61) | P = 0.55 | |
| HoarsenessI2 = 24 % · no statistically significant difference | 0.60 (0.29–1.22) | P = 0.16 | |
| 0.20.5125Relative risk (log scale) |
- Postoperative cough: no statistically significant difference; wide CI suggests a potentially meaningful difference
Original publication
Effect of dexamethasone and lidocaine combination on incidence of post-operative sore throat: A meta-analysis and trial sequential analysis. J Clin Anesth. Published 11 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →