ICU sedation, delirium & recovery
Effect of Enhanced Versus Usual Mobilization Activities in Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Pooled result · Incidence of ICU-acquired weaknessResult — go to the resultRelative risk 0.79 95% CI 0.66–0.95Authors' conclusion
This review demonstrates that enhanced mobilization likely reduces the incidence of ICU-acquired weakness and may reduce duration of delirium, while supporting prior findings that there is little to no difference in risk of adverse events.
Study context
- Population
- Adults (≥ 18 yr) admitted to the ICU
- Participants
- 8,462 adults · 59 randomized controlled trials (RCTs)
- Comparison
- Enhanced mobilization activities vs usual care
- Outcome
- Incidence of ICU-acquired weakness
Methodological detailsGRADE certainty assessment, prospectively registered, 4 databases and 2 trial registries searched until May 2024; review and extraction independently in duplicate
- GRADE certainty assessment
- Prospectively registered
- 4 databases and 2 trial registries searched until May 2024; review and extraction independently in duplicate
Pooled result
As reported in the abstract
Relative risk
0.79
95% CI 0.66–0.95
Enhanced mobilization vs Usual care
RR 0.79 (95% CI 0.66–0.95)
Further pooled results
| Outcome | MD (d) (95% CI) | |
|---|---|---|
| Duration of deliriumLow certainty | −1.34 (−1.85 to −0.83) | |
| Duration of invasive mechanical ventilationModerate certainty | −1.07 (−1.64 to −0.50) | |
| −2−101Difference, d (linear scale) |
ICU and hospital LOS
- May be slightly reduced by enhanced mobilization
- Low certainty
Safety
Adverse events
- Little to no difference
- Low certainty
Original publication
Effect of Enhanced Versus Usual Mobilization Activities in Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Med. Published 14 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →