Effect of epidural anesthesia on the optic nerve sheath diameter in patients with pre-eclampsia: a prospective observational study
Authors' conclusion
Despite a higher baseline ONSD in pre-eclampsia, epidural anesthesia did not further increase ONSD.
Study context
- Population
- Pregnant women receiving de novo epidural anesthesia (21 mL 2% lidocaine + 50 μg fentanyl) for cesarean delivery
- Participants
- 11 vs 11
- Exposure
- Pre-eclampsia vs Normotensive
- Pre-eclampsian = 11
- Normotensiven = 11reference
- Outcome
- Change in ONSD from baseline to 3 min after epidural injection
- Follow-up
- 3 min after epidural injection
Main finding
As reported in the abstract
Change in ONSD from baseline to 3 min · 3 min after injection
- No significant change in optic nerve sheath diameter (ONSD) at 3 min after injection from baseline in either group
- p>0.999
Observational data: associations, not effects.
Further findings
ONSD at baseline · significantly larger in pre-eclampsia
P = 0.001
ONSD 3 min after epidural injection · significantly larger in pre-eclampsia
P < 0.001
Serial ONSD changes after epidural anesthesia (linear mixed model)
- ONSD did not change in Pre-eclampsia
- P = 0.279
- ONSD did not change in Normotensive
- P = 0.347
Original publication
Effect of epidural anesthesia on the optic nerve sheath diameter in patients with pre-eclampsia: a prospective observational study. Reg Anesth Pain Med. Published 30 June 2024. doi:10.
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