Respiratory failure & ventilation
Effect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes: A Randomized Controlled Trial
Primary result · Reintubation or NIVResult — go to the resultRisk difference 5.2% 95% CI −6.7% to 17.1%Authors' conclusion
In unselected extubated patients, setting the HFNC flow rate at 60 L/min did not reduce the risk of reintubation or NIV use compared with a flow rate of 40 L/min.
Study context
- Population
- Unselected intubated patients receiving high-flow nasal cannula (HFNC) after extubation169 analysed
- Participants
- 180 participants
- Comparison
- HFNC at 60 vs 40 L/min after extubation
- 40 L/minn = 86reference
- 60 L/minn = 83
- Primary endpoint
- Composite of:
- Reintubation
- Noninvasive ventilation (NIV) use
- Follow-up
- Within 48 hours after extubation
Primary result
Reintubation or NIV · 48 hours
Risk difference
5.2%
95% CI −6.7% to 17.1%
P = 0.39
Events by treatment group
40 L/min vs 60 L/min
risk difference 5.2% (95% CI −6.7% to 17.1%); P = 0.39
As reported in the abstract
Secondary outcomes
Escalation in respiratory support (NIV or up-titration of HFNC settings) · higher risk in the 40 L/min group
P = 0.002
Original publication
Effect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes: A Randomized Controlled Trial. Chest. Published 30 December 2024. doi:10.
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