Effect of metoclopramide on gastric volume and nausea and vomiting in fasted patients undergoing elective cesarean delivery: a randomized clinical equivalence trial
An erratum to this article was published (Int J Obstet Anesth, Nov 2025 ↗)
Authors' conclusion
In appropriately fasted patients, metoclopramide and saline were equivalent in their effect on gastric volume within ± 17 mL, showing metoclopramide administration had minimal effect on gastric volume in this low-risk population.
Study context
- Population
- Appropriately fasted patients presenting for elective cesarean delivery72 completed
- Comparison
- IV metoclopramide 10 mg vs saline
- Primary endpoint
- Pre- to post-treatment change in gastric volume (gastric ultrasound, Perlas and Roukhomovsky methods); equivalence limits ± 17 mL
- Follow-up
- 30 minutes after study medication
Methodological detailssingle-center, placebo-controlled, equivalence
- Single-center
- Placebo-controlled
- Equivalence
Primary result
As reported in the abstract
Median pre- to post-treatment difference in gastric volume, saline vs metoclopramide
Saline vs MetoclopramideMedian difference, mL (95 % CI)P value
Perlas method
−1(−5 to 2)
P = 0.375Roukhomovsky method
1(−4 to 5)
P = 0.981- Equivalence significant for both methods
- P < 0.001
Further findings
Patients at risk for aspiration (gastric volume > 1.5 mL/kg)
- No differences between groups
Median gastric volume, Roukhomovsky vs Perlas method
- Pre-treatment difference (Roukhomovsky greater)
- 13 mL, P < 0.001
- Post-treatment difference (Roukhomovsky greater)
- 11 mL, P < 0.001
Original publication
Effect of metoclopramide on gastric volume and nausea and vomiting in fasted patients undergoing elective cesarean delivery: a randomized clinical equivalence trial. Int J Obstet Anesth. Published 14 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →