Perioperative medicine & outcomes
Effect of neoadjuvant chemotherapy on intraoperative core temperature in patients with breast cancer: a retrospective cohort study
Main finding · Intraoperative plateau core temperatureResult — go to the resultDifference 0.4 °C 95% CI 0.11–0.63Authors' conclusion
In patients with breast cancer, neoadjuvant chemotherapy is associated with lower plateau core temperatures, increased vasopressor use, and higher heart rates during general anaesthesia, which is more severe in the presence of neuropathy.
Study context
- Population
- Patients undergoing mastectomy for breast cancer, April 2016–July 2020matched cohort
- Participants
- 1,764 patients
- Exposure
- Neoadjuvant chemotherapy vs no prior chemotherapy
- Neoadjuvant chemotherapyn = 882
- No prior chemotherapyn = 882reference
- Outcome
- Intraoperative core temperature patterns
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
Intraoperative plateau core temperature
Difference
0.4 °C
95% CI 0.11–0.63
P = 0.005
No prior chemotherapy vs Neoadjuvant chemotherapy
difference 0.4 °C (95% CI 0.11–0.63); P = 0.005
As reported in the abstract
Observational data: associations, not effects.
Further findings
Vasopressor use and heart rate, neuropathy in neoadjuvant chemotherapy patients (subgroup)
- Neuropathy associated with increased vasopressor use and higher heart rate
Original publication
Effect of neoadjuvant chemotherapy on intraoperative core temperature in patients with breast cancer: a retrospective cohort study. BJA Open. Published 31 December 2022. doi:10.
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