Effect of nociception level index‐guided intra‐operative analgesia on early postoperative pain and opioid consumption: a systematic review and meta‐analysis
Authors' conclusion
Our meta-analysis of the current literature finds that nociception level index-guided analgesia statistically significantly reduces reported postoperative pain intensity and opioid consumption but fails to show clinically relevant outcomes.
Study context
- Population
- Patients undergoing surgery with intra-operative analgesia
- Participants
- 662 patients · 10 studies
- Comparison
- Nociception level index-guided analgesia vs standard care
- Outcome
- Pain intensity and opioid consumption
- Follow-up
- First 60-120 min after surgery
Methodological detailsrandom-effects model, Risk of methodological bias generally low or unclear
- Random-effects model
- Risk of methodological bias generally low or unclear
Pooled result
As reported in the abstract
NOL-guided vs Standard careMean difference (pain, 11-point scale) (95% CI)P value
11-point scale
−0.46(−0.88 to −0.03)
P = 0.03NOL-guided vs Standard careMean difference (opioid requirement), mg intravenous morphine equivalent (95% CI)P value
NOL-guided
−1.04(−1.94 to −0.15)
P = 0.02Further pooled results
- No evidence that NOL-guided analgesia affected PONV nor PACU LOS
Original publication
Effect of nociception level index‐guided intra‐operative analgesia on early postoperative pain and opioid consumption: a systematic review and meta‐analysis. Anaesthesia. Published 21 October 2023. doi:10.
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