Pediatric anesthesia & critical care
Effects of goal-directed analgesia using the analgesia nociception index in children undergoing surgery for moyamoya disease: A randomised controlled trial
Primary result · Intra-operative sufentanil consumptionResult — go to the resultMean difference −0.09 μg kg −1 h −1 95% CI −0.19 to 0.00Authors' conclusion
The Analgesia Nociception Index guided analgesic protocol can reduce intra-operative sufentanil consumption and postoperative pain within 24 h with fewer nausea symptoms in paediatric patients with moyamoya disease who undergo encephaloduroarteriosynangiosis.
Study context
- Population
- Children with moyamoya disease scheduled for encephaloduroarteriosynangiosis, Seoul National University Children's Hospital, Republic of Korea
- Participants
- 40 children
- Comparison
- Analgesia Nociception Index guided analgesia vs standard analgesia
- Primary endpoint
- Total intra-operative sufentanil consumption
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
Intra-operative sufentanil consumption
Mean difference
−0.09 μg kg −1 h −1
95% CI −0.19 to 0.00
P = 0.049
By group
Analgesia Nociception Index vs Standard
mean difference −0.09 μg kg −1 h −1 (95% CI −0.19 to 0.00); P = 0.049
As reported in the abstract
Secondary outcomes
Median
| Outcome | Analgesia Nociception Index | Standard | P value |
|---|---|---|---|
| Pain score · 18 h | 1 (IQR 0–2) | 3 (IQR 2–5) | P = 0.004 |
| Pain score · 24 h | 1 (IQR 0–2) | 3 (IQR 1–4) | P = 0.041 |
| Maximum pain score · within 24 h | 4 (IQR 3–5) | 5 (IQR 4–7) | P = 0.045 |
Safety
Nausea · postoperative
P = 0.043
Original publication
Effects of goal-directed analgesia using the analgesia nociception index in children undergoing surgery for moyamoya disease: A randomised controlled trial. Eur J Anaesthesiol. Published 3 June 2024. doi:10.
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