Pediatric anesthesia & critical care
Goal‐directed fluid therapy guided by plethysmographic variability index versus conventional liberal fluid therapy in neonates undergoing abdominal surgery: A prospective randomized controlled trial
Primary result · Total intraoperative fluid infusedResult — go to the resultMedian difference −15 95% CI −49.1 to 19.1Authors' conclusion
Intraoperative plethysmographic variability index-guided goal-directed fluid therapy was comparable to liberal fluid therapy in terms of total volume of fluid infused in neonates during perioperative period.
Study context
- Population
- Term neonates undergoing abdominal surgerycompleted
- Participants
- 30 neonates
- Comparison
- PVI-guided GDFT vs liberal fluid therapy
- Primary endpoint
- Total amount of fluid infused intraoperatively
Methodological detailsprospective, single-centre (tertiary care centre), Conducted over 18 months
- Prospective
- Single-centre (tertiary care centre)
- Conducted over 18 months
Primary result
Total intraoperative fluid infused
Median difference
−15
95% CI −49.1 to 19.1
P = 0.406
By group
GDFT vs Liberal fluid therapy
median difference −15 (95% CI −49.1 to 19.1); P = 0.406
As reported in the abstract
Secondary outcomes
| Outcome | GDFT | Liberal fluid therapy | Median difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Fluid infused before dopamine administrationSignificantly higher in liberal group | 36 (range (as printed) 22–44) mL | 58 (range (as printed) 50.25–65) mL | −22 (−46 to 2) | P = 0.008 | |
| Total postoperative fluid intake · 24 hComparable | 222 (range (as printed) 204–253) mL | 224 (range (as printed) 179.5–289.5) mL | −2 (−65.3 to 61.2) | P = 0.917 | |
| −100−50050100Difference (linear scale) |
Serum lactate · preoperative to postoperative 24 h
- Decrease in serum lactate in both groups
Original publication
Goal‐directed fluid therapy guided by plethysmographic variability index versus conventional liberal fluid therapy in neonates undergoing abdominal surgery: A prospective randomized controlled trial. Paediatr Anaesth. Published 13 February 2024. doi:10.
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