Effect of Propofol on Heart Rate and Its Coupling to Cortical Slow Waves in Humans
Authors' conclusion
The authors observed a robust increase in heart rate with increasing propofol concentrations in healthy volunteers and patients.
Study context
- Population
- Healthy volunteers receiving slow propofol infusion up to estimated effect-site concentration 4 µg/ml; older ASA II/III clinical population (AlphaMax trial)
- Participants
- 16 healthy volunteers
Methodological detailspost hoc analysis in AlphaMax trial population
- Post hoc analysis in AlphaMax trial population
Primary result
As reported in the abstract
Heart rate with propofol concentration
Dose-dependent HR increase, mean ± SD (beats/min/[μg ml-1]); P < 0.001
+4.2 ± 1.5
Further findings
ECG R-wave amplitude (healthy volunteers)
- Decrease, median [25th to 75th percentile] (μV); P < 0.001
- −83 [−245 to −28]
Heart rate variability
- Loss of high-frequency parasympathetic activity
Coupling of cortical slow waves to heartbeat
- Individual cortical slow waves coupled to the heartbeat; heartbeat incidence peaked about 450 ms before slow-wave onset
- Mean slow-wave frequency correlated with mean HR
Original publication
Effect of Propofol on Heart Rate and Its Coupling to Cortical Slow Waves in Humans. Anesthesiology. Published 6 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →