Pediatric anesthesia & critical care
Effect of Tulobuterol Patch Versus Placebo on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomies: A Randomized Controlled Trial
Primary result · Any perioperative respiratory adverse eventResult — go to the resultAverage RR across components 0.35 95% CI 0.20–0.60Authors' conclusion
In preschool children undergoing tonsillectomy, the preoperative application of a tulobuterol patch could decrease the occurrence of perioperative respiratory adverse events.
Study context
- Population
- Pediatric patients undergoing tonsillectomy88 and 94 analysed
- Participants
- 188 patients
- Comparison
- Tulobuterol patch vs placebo, applied 8 to 10 hours before surgery
- Tulobuteroln = 88
- Placebon = 94reference
- Primary endpoint
- Any perioperative respiratory adverse event: oxygen desaturation <95%, airway obstruction, laryngospasm, bronchospasm, severe coughing, or stridor (average relative effect test across components)
Methodological detailstriple-blinded (patient, anesthesia provider, and outcome assessor), placebo-controlled
- Triple-blinded (patient, anesthesia provider, and outcome assessor)
- Placebo-controlled
Primary result
Any perioperative respiratory adverse event
Average RR across components
0.35
95% CI 0.20–0.60
P < 0.001
Events by treatment group
Tulobuterol vs Placebo
average RR across components 0.35 (95% CI 0.20–0.60); P < 0.001
As reported in the abstract
Further findings
| Outcome | Tulobuterol | Placebo | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Airway obstruction | 9.0% | 34.0% | 0.31 (0.17–0.56) | P < 0.001 | |
| Severe coughing | 1.1% | 8.5% | 0.15 (0.03–0.68) | P = 0.014 | |
| 0.050.21520Relative risk (log scale) |
Original publication
Effect of Tulobuterol Patch Versus Placebo on the Occurrence of Respiratory Adverse Events in Children Undergoing Tonsillectomies: A Randomized Controlled Trial. Anesth Analg. Published 19 May 2023. doi:10.
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