Respiratory failure & ventilation
Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial
Authors' conclusion
This pilot trial established the feasibility of conducting a cluster-randomized crossover trial of ventilator mode among critically ill adults receiving invasive mechanical ventilation and demonstrated differences in intermediate outcomes that warrant further investigation in a larger trial.
Study context
- Population
- Adults receiving invasive mechanical ventilation in a medical ICU, November 1, 2022 to July 31, 2023included in primary analysis
- Participants
- 566 adults
- Comparison
- Volume control vs Pressure control
- Primary endpoint
- Ventilator-free days
- Follow-up
- 28 days
Methodological detailspragmatic, cluster-randomized, crossover, pilot
- Pragmatic
- Cluster-randomized
- Crossover
- Pilot
Primary result
As reported in the abstract
P = 0.60
Further findings
Median
| Outcome | Volume control | Pressure control | Adaptive pressure control |
|---|---|---|---|
| Percentage of breaths > 8 mL/kg of predicted body weight | 4.0% (IQR 0.0%–14.1%) | 10.6% (IQR 0.0%–31.5%) | 4.7% (IQR 0.0%–19.2%) |
Adherence: median proportion of ventilator mode assessments in assigned mode · first 72 hours
- Median 100% in each group
Tidal volume
- Median tidal volume similar among the 3 groups
Percentage of breaths > 8 mL/kg of predicted body weight
- Differed among the 3 groups
Original publication
Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial. Chest. Published 4 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →