Respiratory failure & ventilation
A randomized controlled trial comparing non-invasive ventilation delivered using neurally adjusted ventilator assist (NAVA) or adaptive support ventilation (ASV) in patients with acute exacerbation of chronic obstructive pulmonary disease
Authors' conclusion
The use of NAVA-NIV was not superior to ASV-NIV in reducing NIV failure rates in AECOPD.
Study context
- Population
- Consecutive patients with acute exacerbation of COPD74% males
- Participants
- 76 patients
- Comparison
- NAVA-NIV vs ASV-NIV
- NAVA-NIVn = 36
- ASV-NIVn = 40reference
- Primary endpoint
- NIV failure rate (invasive mechanical ventilation)
Primary result
As reported in the abstract
P = 0.83
Secondary outcomes
90-day mortality · no difference
P = 0.67
Median
| Outcome | NAVA-NIV | ASV-NIV | P value |
|---|---|---|---|
| Physician manipulations for NIV · initial 24-hSignificantly less with ASV-NIV | 3 (range 2–5) | 2 (range 0.8–4) | P = 0.014 |
| Asynchrony indexNo difference | 16.6% | 16.4% | P = 0.5 |
Original publication
A randomized controlled trial comparing non-invasive ventilation delivered using neurally adjusted ventilator assist (NAVA) or adaptive support ventilation (ASV) in patients with acute exacerbation of chronic obstructive pulmonary disease. J Crit Care. Published 19 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →