Neuroanesthesia & neurocritical care
Effect of Preoperative Intravenous Ferric Carboxymaltose on Postoperative Transfusion Reduction in Iron Deficiency Anemia Patients Scheduled for Clipping Surgery for Unruptured Intracranial Aneurysms: The PICASA Trial — A Single Center, Single-Blind Randomized Clinical Trial
Primary resultResult — go to the resultOdds ratio 0.03 95% CI 0–0.28Authors' conclusion
Preoperative FCM administration significantly reduced the need for perioperative RBCT and improved anemia-related biomarkers in patients with IDA undergoing clipping for UIAs, with no adverse events reported.
Study context
- Population
- Patients with iron deficiency anaemia scheduled for microsurgical clipping of unruptured intracranial aneurysmsrandomised
- Participants
- 31 patients
- Comparison
- Ferric carboxymaltose (FCM) vs Control
- FCMn = 17
- Controln = 14reference
- Primary endpoint
- Incidence of RBC transfusion
Methodological detailssingle-blind, single-centre
- Single-blind
- Single-centre
Primary result
As reported in the abstract
Odds ratio
0.03
95% CI 0–0.28
P < 0.001
Events by treatment group
FCM
0
events
Control
57.1%
Secondary outcomes
| Outcome | P value |
|---|---|
| Hb and ferritin levels throughout observation periodFCM vs Control · significantly higher in FCM group | P = 0.011 |
| Hb and ferritin levels throughout observation periodFCM vs Control · significantly higher in FCM group | P < 0.001 |
Hemoglobin (Hb) increase in FCM group by day before surgery
- Hb increased significantly in the FCM group
- P = 0.023
Safety
- FCM-related adverse events
- 0 · events
FCM-related adverse events
- No FCM-related adverse events reported
Original publication
Effect of Preoperative Intravenous Ferric Carboxymaltose on Postoperative Transfusion Reduction in Iron Deficiency Anemia Patients Scheduled for Clipping Surgery for Unruptured Intracranial Aneurysms: The PICASA Trial — A Single Center, Single-Blind Randomized Clinical Trial. Anaesth Crit Care Pain Med. Published 24 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →