Neuroanesthesia & neurocritical care
Endovascular embolization for ruptured intracranial aneurysms: efficacy and effects on oxidative stress levels
Authors' conclusion
Compared with microscopic aneurysm clipping, endovascular embolization offers better efficacy for patients with RIA and causes less vascular endothelial damage.
Study context
- Population
- Patients with ruptured intracranial aneurysms (RIAs)
- Participants
- 89 patients
- Comparison
- Endovascular embolization vs aneurysm clipping surgery
- Observationn = 47
- Controln = 42reference
- Outcome
- Efficacy of endovascular embolization (therapeutic effect)
Main finding
As reported in the abstract
Therapeutic effect
- Therapeutic effect better in the observation group
- Observation vs Control: P = 0.041
Further findings
| Outcome | P value |
|---|---|
| NIHSS score, SOD and MDA levels · 7 days post-treatmentAll comparisons | P < 0.001 |
| Intraoperative bleeding, operative time, hospital stay, vWF, ET-1 and NOAll comparisons | P < 0.001 |
National Institutes of Health Stroke Scale (NIHSS) score, superoxide dismutase (SOD) and malondialdehyde (MDA) levels · 7 days post-treatment
- Lower NIHSS scores, higher SOD levels and lower MDA levels in the observation group
Intraoperative bleeding, operative time, hospital stay, von Willebrand factor (vWF), ET-1 and nitric oxide (NO)
- Less intraoperative bleeding, shorter operation times and hospital stays, lower vWF and ET-1, higher NO in the observation group
Safety
| Outcome | P value |
|---|---|
| Postoperative complications | P = 0.048 |
Postoperative complications
- Lower incidence of postoperative complications in the observation group
Original publication
Endovascular embolization for ruptured intracranial aneurysms: efficacy and effects on oxidative stress levels. Perioper Med (Lond). Published 2 September 2025. doi:10.
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