Respiratory failure & ventilation
Effect of transnasal humidified rapid-insufflation ventilatory exchange on gastric insufflation during anaesthesia induction: A randomised controlled trial and multivariate analysis
Primary resultResult — go to the resultOdds ratio 0.27 95% CI 0.14–0.56Authors' conclusion
During anaesthesia induction, the THRIVE technique provided adequate oxygenation with a reduced incidence of gastric insufflation.
Study context
- Population
- Adults (>18 years, ASA I to III) undergoing GA, single centre, China, May–September 2022
- Participants
- 210 adults
- Comparison
- Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) vs pressure-controlled facemask ventilation (PCFV)
- Primary endpoint
- Incidence of gastric insufflation (real-time ultrasonography) from loss of consciousness until intubation
Methodological detailsprospective, double-blind, single-centre
- Prospective
- Double-blind
- Single-centre
Primary result
As reported in the abstract
Odds ratio
0.27
95% CI 0.14–0.56
P < 0.001
By group
THRIVE
13.0
%
PCFV
35.3%
THRIVE vs PCFV
OR 0.27 (95% CI 0.14–0.56); P < 0.001
Further findings
Increase in antral CSA after induction and gastric insufflation
| OR (95% CI) | P value | ||
|---|---|---|---|
| Increase in CSA | 5.35 (2.90–9.89) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Independent risk factors for gastric insufflation (multivariate logistic regression)
| OR (95% CI) | ||
|---|---|---|
| Advancing age | 1.04 (1.01–1.07) | |
| OSA syndrome | 2.43 (1.24–4.76) | |
| Higher Mallampati score | 2.66 (1.21–5.85) | |
| PCFV | 4.78 (2.06–11.06) | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Effect of transnasal humidified rapid-insufflation ventilatory exchange on gastric insufflation during anaesthesia induction: A randomised controlled trial and multivariate analysis. Eur J Anaesthesiol. Published 12 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →