Respiratory failure & ventilation
Physiological effects of trans-nasal humidified rapid insufflation ventilatory exchange (transnasal humidified rapid insufflation ventilatory exchange (THRIVE)) on lung volume dynamics during controlled apnea in patients with obesity: a randomized controlled trial
Primary resultResult — go to the resultMean difference 0.67 95% CI 0.55–0.80Authors' conclusion
In obese patients, THRIVE transiently preserves lung volume during early apnea by slowing the decline in end-expiratory lung volume.
Study context
- Population
- Adults with BMI ≥35 kg/m² undergoing elective surgery32 analysed
- Comparison
- THRIVE vs facemask oxygen for apneic oxygenation after GA induction
- Primary endpoint
- Mean global change in end-expiratory lung impedance (ΔEELI, surrogate of lung volume, by electrical impedance tomography)
- Follow-up
- Early apneic window (2-6 min)
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Mean difference
0.67
95% CI 0.55–0.80
P < 0.001
By group
THRIVE
−0.22
mean · SD 0.03
Facemask oxygen
−0.89
mean · SD 0.07
THRIVE vs Facemask oxygen
mean difference 0.67 (95% CI 0.55–0.80); P < 0.001
Further findings
Safe apnea time · significantly prolonged with THRIVE
Rate of ΔEELI decline and regional lung volume
- THRIVE attenuated rate of ΔEELI decline; greater lung volume preservation, particularly mid-ventral and mid-dorsal regions
Original publication
Physiological effects of trans-nasal humidified rapid insufflation ventilatory exchange (THRIVE) on lung volume dynamics during controlled apnea in patients with obesity: a randomized controlled trial. J Clin Anesth. Published 25 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →