Anaesthetic drugs & techniques
Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial
Primary resultResult — go to the resultDifference −19.14 95% CI −23.09 to −15.36Authors' conclusion
In patients with obesity, oxygenation via HFNC during sedated gastrointestinal endoscopy significantly reduced the incidences of hypoxia, subclinical respiratory depression, and severe hypoxia without increasing other adverse events.
Study context
- Population
- Adults with obesity (BMI ≥28) scheduled for GI endoscopy sedated with propofol and low dose sufentanil, 3 tertiary hospitals in Shanghai, China984 completed and analysed
- Participants
- 1,000 adults
- Comparison
- High flow nasal cannula (HFNC) vs regular nasal cannula oxygenation during sedated GI endoscopy
- HFNCn = 497
- Regular nasal cannulan = 487reference
- Primary endpoint
- Hypoxia (75%≤SpO2<90% for <60 s)
- Follow-up
- During the procedure
Methodological detailsmulticentre, parallel group, 6 May 2021 to 26 May 2023
- Multicentre
- Parallel group
- 6 May 2021 to 26 May 2023
Primary result
As reported in the abstract
Difference
−19.14
95% CI −23.09 to −15.36
P < 0.001
Events by treatment group
HFNC vs Regular nasal cannula
difference −19.14 (95% CI −23.09 to −15.36); P < 0.001
Secondary outcomes
| Outcome | HFNC | Regular nasal cannula | Difference (CI) | P value | |
|---|---|---|---|---|---|
| Subclinical respiratory depression (90%≤SpO2<95% for any duration) | 5.6% | 36.3% | −30.71 (−35.40 to −25.92) | P < 0.001 | |
| −40−20020Difference (linear scale) |
| Outcome | HFNC | Regular nasal cannula | Difference (%) (CI) | P value | |
|---|---|---|---|---|---|
| Severe hypoxia (SpO2<75% any duration or 75%≤SPO2<90% for >60 s) | 0% | 4.1% | −4.11 (−6.26 to −2.48) | P < 0.001 | |
| −10−505Difference, % (linear scale) |
Safety
Other sedation related adverse events
- Did not differ between the two groups
Original publication
Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial. BMJ. Published 11 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →