Anaesthetic drugs & techniques
Comparison of different weight-based scalars of remimazolam for anesthesia induction in patients with obesity: a randomized controlled trial
Authors' conclusion
At 12 mg·kg-1·hr-1 iv, remimazolam dosing based on LBW in patients with obesity resulted in equivalent induction doses compared with normal-weight patients dosed by TBW. Total-body-weight-based dosing in patients with obesity resulted in a shorter duration to LOC.
Study context
- Population
- Patients with obesity undergoing GA induction with remimazolam, and normal-weight controls; Eye and ENT Hospital of Fudan University, Shanghai, China40 randomised
- Participants
- 60 patients
- Comparison
- Remimazolam induction dosed by lean body weight (LBW) vs total body weight (TBW) in patients with obesity, with normal-weight controls dosed by TBW
- LBWn = 20
- TBWn = 20
- Control (TBW)n = 20reference
- Primary endpoint
- Induction dose (mg·kg-1) for MOAA/S 0 achievement (loss of consciousness (LOC))
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
As reported in the abstract
Induction dose of remimazolam
P < 0.001
Original publication
Comparison of different weight-based scalars of remimazolam for anesthesia induction in patients with obesity: a randomized controlled trial. Can J Anaesth. Published 1 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →