Hemodynamic effects of a low versus a high dose of propofol during induction of anesthesia. A randomized trial
Primary resultResult — go to the resultSAP change difference −2.9 mmHg 95% CI −9.0-3.1Authors' conclusion
A high dose of propofol was not inferior to a low dose, and a reduction in the dose of propofol did not result in clinically important attenuation of major hemodynamic changes during induction in healthy women.
Study context
- Population
- Healthy women scheduled for gynecological surgery, Day Surgery Unit, Haugesund Hospital, Norway
- Participants
- 68 women
- Comparison
- Low vs high dose propofol for induction
- Primary endpoint
- Change in SBP (a 10 mmHg difference considered clinically important)
Methodological detailsdouble-blind, dose-controlled, non-inferiority, Remifentanil 1.9-2.0 μg/kg total body weight (TBW) (maximal concentrations (Ce) 5.0 ng/mL); invasive beat-to-beat monitoring with LiDCOplus over 450 s
- Double-blind
- Dose-controlled
- Non-inferiority
- Remifentanil 1.9-2.0 μg/kg TBW (maximal Ce 5.0 ng/mL); invasive beat-to-beat monitoring with LiDCOplus over 450 s
Primary result
As reported in the abstract
SAP change difference
−2.9 mmHg
95% CI −9.0-3.1
Low dose vs High dose
SAP change difference −2.9 mmHg (95% CI −9.0-3.1)
Non-inferiority margin 10 as printed, not drawn
Further findings
| Outcome | Low dose | High dose | P value |
|---|---|---|---|
| Relative change in SBP | −31% | −36% | P < 0.01 |
| Relative change in HR | −24% | −20% | P = 0.09 |
| Relative change in systemic vascular resistance | −20% | −31% | P < 0.001 |
| Relative change in stroke volume | −16% | −20% | P = 0.04 |
| Relative change in CO | −35% | −32% | P = 0.33 |
Original publication
Hemodynamic effects of a low versus a high dose of propofol during induction of anesthesia. A randomized trial. Acta Anaesthesiol Scand. Published 8 June 2023. doi:10.
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