Perioperative medicine & outcomes
Effect of two-session remote ischaemic preconditioning on myocardial injury after noncardiac surgery in patients undergoing abdominal surgery: a randomised clinical trial
Authors' conclusion
In patients undergoing abdominal surgery, two-session RIPC did not reduce the incidence of MINS.
Study context
- Population
- Patients undergoing abdominal surgery (median age 71 yr; 33.7% female)randomised
- Participants
- 766 patients
- Comparison
- Two-session remote ischaemic preconditioning (RIPC) vs sham procedure
- RIPCn = 368
- Controln = 368reference
- Primary endpoint
- Incidence of MINS (AHA definition)
Methodological detailsprospective, two-centre, observer-blinded, sham-controlled
- Prospective
- Two-centre
- Observer-blinded
- Sham-controlled
Primary result
As reported in the abstract
Adjusted relative risk
1.04
95% CI 0.76–1.41
P = 0.808
Events by treatment group
RIPC vs Control
adjusted RR 1.04 (95% CI 0.76–1.41); P = 0.808
Secondary outcomes
| Outcome | Median difference (ng L-1) (95% CI) | P value | |
|---|---|---|---|
| Total high-sensitivity cardiac troponin T release · first 3 postoperative daysHigher in the RIPC group | 32 (12–52) | P = 0.002 | |
| −50050100Difference, ng L-1 (linear scale) |
Secondary cardiovascular outcomes
- No significant differences between groups
Original publication
Effect of two-session remote ischaemic preconditioning on myocardial injury after noncardiac surgery in patients undergoing abdominal surgery: a randomised clinical trial. Br J Anaesth. Published 21 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →