Perioperative medicine & outcomes
Remote Ischemic Preconditioning and Survival in Noncardiac Surgery: An Updated Meta-analysis of Randomized Trials
Pooled resultResult — go to the resultOdds ratio 0.79 95% CI 0.51–1.24Authors' conclusion
RIPC was not associated with a significant reduction in mortality in the noncardiac surgical population, except for the subgroup of patients who received RIPC before anesthesia induction. However, RIPC showed beneficial effects on biomarkers of renal damage, stroke rate, and length of hospital stay.
Study context
- Population
- Adults undergoing noncardiac surgery
- Participants
- 9,340 adults · 79 RCTs
- Comparison
- Remote ischemic preconditioning (RIPC) vs control
- Outcome
- All-cause mortality
- Follow-up
- Longest available
Methodological detailsrandom-effects models, Cochrane risk-of-bias tool version 2, Predominantly single-centre RCTs; abdominal surgery most prevalent setting (25 studies)
- Random-effects models
- Cochrane risk-of-bias tool version 2
- Predominantly single-centre RCTs; abdominal surgery most prevalent setting (25 studies)
Pooled result
As reported in the abstract
Odds ratio
0.79
95% CI 0.51–1.24
P = 0.30
RIPC vs Control
OR 0.79 (95% CI 0.51–1.24); P = 0.30
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Mortality, subgroup receiving RIPC before anesthesia induction (subgroup) | 0.37 (0.17–0.81) | P = 0.013 | |
| Stroke (exploratory) | 0.41 (0.22–0.78) | P = 0.006 | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | Estimate | P value |
|---|---|---|
| Hospital LOS (exploratory) | mean difference −0.84 days | P < 0.001 |
| Peak postoperative serum NGAL (exploratory) | mean difference −10.27 | P = 0.008 |
Original publication
Remote Ischemic Preconditioning and Survival in Noncardiac Surgery: An Updated Meta-analysis of Randomized Trials. Anesth Analg. Published 3 September 2026. doi:10.
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