Effect of Ultrasound‐Guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures: A Randomized Controlled Noninferiority Trial
Authors' conclusion
Lateral infraclavicular block with ropivacaine 0.2% failed to demonstrate noninferiority for block success and was statistically inferior to ropivacaine 0.5%.
Study context
- Population
- Adults with distal radius fractures requiring closed reduction
- Participants
- 63 adults
- Comparison
- Lateral infraclavicular block with lidocaine 1% with epinephrine or ropivacaine 0.2% vs ropivacaine 0.5% (30 mL)
- Primary endpoint
- Block success: complete sensory and extensive motor block of the radial, musculocutaneous, ulnar, and median nerves
- Follow-up
- 45 min
Methodological detailsblinded, noninferiority, three-arm
- Blinded
- Noninferiority
- Three-arm
Primary result
As reported in the abstract
Each group vs ropivacaine 0.5%Relative risk (97.5% CI)
Ropivacaine 0.2%statistically inferior
0.63(0.40–0.99)
Lidocaine 1% with epinephrinedid not meet the predefined noninferiority criteria
0.95(0.73–1.22)
Non-inferiority margin 20 as printed, not drawn
Further findings
Analgesia and block duration (exploratory)
- Lidocaine 1% with epinephrine provided comparable analgesia with a shorter block duration
Pain during reduction (exploratory)
- Pain scores low across all groups, with a significant decrease from baseline
Patient satisfaction (exploratory)
- High in all groups
Quality of closed reduction and fracture treatments (exploratory)
- No significant differences
Safety
- No significant differences
Original publication
Effect of Ultrasound‐Guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures: A Randomized Controlled Noninferiority Trial. Acta Anaesthesiol Scand. Published 9 May 2026. doi:10.
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