The effect of combining lidocaine and ropivacaine on the duration and onset time of an ultrasound-guided infraclavicular brachial plexus nerve block: A randomised controlled trial
Authors' conclusion
Mixing lidocaine-epinephrine with ropivacaine significantly shortened the duration of analgesia by up to 5 h without affecting the sensory onset time. This effect was independent of the ropivacaine dose.
Study context
- Population
- Patients undergoing hand surgery under lateral infraclavicular brachial plexus nerve block, tertiary hospital, Capital Region of Denmark, 18 April–23 November 2024
- Participants
- 78 patients
- Comparison
- Ropivacaine mixed with lidocaine-epinephrine vs ropivacaine alone
- Primary endpoint
- Duration of analgesia
Methodological detailsblinded, active-controlled, superiority, three-arm, single tertiary hospital
- Blinded
- Active-controlled
- Superiority
- Three-arm
- Single tertiary hospital
Primary result
As reported in the abstract
Difference, min (95% CI)P value
R100-L200 vs R150-L200not statistically significant after adjustment for multiple testing
135(13–257)
P = 0.031- R100-L200 vs R150 · reduced vs R150
- mean difference (reduction) 311 min (95% CI 212–411); P < 0.001
- R150-L200 vs R150 · reduced vs R150
- mean difference (reduction) 177 min (95% CI 64–289); P = 0.003
Secondary outcomes
Sensory onset time
- Ranged insignificantly across groups
- 17 to 18 min
Original publication
The effect of combining lidocaine and ropivacaine on the duration and onset time of an ultrasound-guided infraclavicular brachial plexus nerve block: A randomised controlled trial. Eur J Anaesthesiol. Published 1 September 2025. doi:10.
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