The effect of oral dexamethasone on duration of analgesia after upper limb surgery under infraclavicular brachial plexus block: a randomised controlled trial
Authors' conclusion
Both 24 mg and 12 mg of oral dexamethasone increased the time until first postoperative pain compared with placebo in patients having upper limb surgery under infraclavicular brachial plexus block.
Study context
- Population
- Adults scheduled for forearm or hand surgery under lateral infraclavicular brachial plexus block
- Participants
- 61 / 61 / 57
- Comparison
- Oral dexamethasone 12 mg or 24 mg vs placebo before lateral infraclavicular block
- Placebon = 61reference
- Dexamethasone 12 mgn = 61
- Dexamethasone 24 mgn = 57
- Primary endpoint
- Time until first pain after block
Methodological detailsplacebo-controlled, three-arm
- Placebo-controlled
- Three-arm
Primary result
As reported in the abstract
Placebo
841
mean · SD 327 · min
Mean difference, min (98.3% CI)P value
Dexamethasone 24 mg vs Placebo
412(248–577)
P < 0.001Dexamethasone 24 mg vs Dexamethasone 12 mg
85(−78 to 249)
P = 0.21Dexamethasone 12 mg vs Placebo
330(186–474)
P < 0.001Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The effect of oral dexamethasone on duration of analgesia after upper limb surgery under infraclavicular brachial plexus block: a randomised controlled trial. Anaesthesia. Published 21 October 2023. doi:10.
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