Effective bolus dose of remimazolam for i-gel® insertion in nonparalyzed patients: a dose-finding study
Authors' conclusion
This regimen seems effective with a low risk of hemodynamic instability during anesthesia induction.
Study context
- Population
- Adults scheduled for surgery under GA eligible for i-gel use, without neuromuscular blocking agents (NMBAs)
- Participants
- 25 adults
- Outcome
- Effective bolus dose (ED50, ED95) of remimazolam for successful i-gel insertion, attempted 90 sec after administration
Methodological detailsmodified Dixon's up-and-down method, isotonic regression
- Modified Dixon's up-and-down method
- Isotonic regression
Main finding
As reported in the abstract
ED50 and ED95 of remimazolam bolus for successful i-gel insertion
Remimazolam
0.100
mean · SD 0.027 · mg·kg-1
- Effective dose (ED50) by isotonic regression, mg·kg-1
- 0.111 (83% CI 0.096 to 0.131)
- ED95 by isotonic regression, mg·kg-1
- 0.182 (95% CI 0.144 to 0.195)
Safety
Treatment for hypotension or bradycardia during anesthesia induction
- No patients required treatment for hypotension or bradycardia
Original publication
Effective bolus dose of remimazolam for i-gel® insertion in nonparalyzed patients: a dose-finding study. Can J Anaesth. Published 26 April 2024. doi:10.
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