Effectiveness of dexmedetomidine on patient-centred outcomes in surgical patients: a systematic review and Bayesian meta-analysis
Pooled result · Postoperative QoR-15Result — go to the resultMean difference 9 95% CrI 4–14Authors' conclusion
Compared with placebo or standard of care, intraoperative dexmedetomidine likely results in meaningful improvement in the quality of recovery and chronic pain after surgery. However, it might increase clinically important bradycardia and hypotension.
Study context
- Population
- Adults requiring surgery under GA
- Participants
- 5,904 adults · 44 randomised controlled trials (RCTs)
- Comparison
- Intraoperative dexmedetomidine vs placebo, opioid, or usual care
- Outcome
- Quality of recovery after surgery
Methodological detailsrandom-effects Bayesian regression, Grading of Recommendations Assessment, Development and Evaluation (GRADE) certainty assessment
- Random-effects Bayesian regression
- GRADE certainty assessment
Pooled result
Postoperative QoR-15
Mean difference
9
95% CrI 4–14
Dexmedetomidine vs Placebo, opioid, or usual care
mean difference 9 (95% CrI 4–14)
As reported in the abstract
- Probability of any benefit
- 99%
- Probability of achieving the MID
- 88%
Further pooled results
Chronic pain incidence
- Reduced chronic pain incidence, OR
- 0.42 (0.19-0.79) (95% CrI)
- n=7 RCTs
- Low certainty of evidence
Other secondary patient-centred outcomes
- Limited evidence to inform other secondary patient-centred outcomes
Safety
Clinically significant hypotension
- Increased risk of clinically significant hypotension, OR
- 1.98 (0.84-3.92) (95% CrI)
- Posterior probability of harm
- 94%
- n=8 RCTs
- Very low certainty of evidence
Clinically significant bradycardia
- Increased risk of clinically significant bradycardia, OR
- 1.74 (0.93-3.34) (95% CrI)
- Posterior probability of harm
- 95%
- n=10 RCTs
- Very low certainty of evidence
Original publication
Effectiveness of dexmedetomidine on patient-centred outcomes in surgical patients: a systematic review and Bayesian meta-analysis. Br J Anaesth. Published 16 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →