Respiratory failure & ventilation
The effectiveness of supplemental oxygen and high-flow nasal cannula therapy in patients with obstructive sleep apnea in different clinical settings: A systematic review and meta-analysis
Authors' conclusion
Oxygen therapy effectively reduces AHI and increases SpO2 in patients with OSA. CPAP is more effective in reducing AHI than oxygen therapy. HFNC therapy is effective in reducing AHI.
Study context
- Population
- Patients with obstructive sleep apnea (OSA) in different clinical settings36 studies
- Comparison
- Oxygen therapy and high-flow nasal cannula (HFNC) therapy vs baseline; CPAP vs oxygen therapy
- Oxygen therapyn = 1,395
- HFNC therapyn = 228
- Outcome
- AHI and SpO2
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
- Oxygen therapy significantly reduced apnea-hypopnea index (AHI) vs baseline
- 31%
- Oxygen therapy increased SpO2 vs baseline
- 5%
- CPAP significantly reduced AHI vs baseline
- 84%
- CPAP increased SpO2 vs baseline
- 3%
- CPAP more effective in reducing AHI than oxygen therapy
- 53%
- HFNC therapy significantly reduced AHI
- 36%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The effectiveness of supplemental oxygen and high-flow nasal cannula therapy in patients with obstructive sleep apnea in different clinical settings: A systematic review and meta-analysis. J Clin Anesth. Published 10 May 2023. doi:10.
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