The effects of blood cell salvage on transfusion requirements after decannulation from veno-venous extracorporeal membrane oxygenation: an emulated trial analysis
Main finding · PRBC units transfusedResult — go to the resultAverage treatment effect −0.31 units 95% CI −0.40 to −0.22Authors' conclusion
The use of BCS during VV-ECMO decannulation may be an effective strategy to augment haemoglobin levels and reduce PRBC transfusions.
Study context
- Population
- Patients undergoing veno-venous extracorporeal membrane oxygenation (VV-ECMO) decannulation at two UK ECMO centres
- Participants
- 841 patients
- Exposure
- Blood cell salvage vs no blood cell salvage at VV-ECMO decannulation
- Outcome
- Packed red blood cells (PRBC) units transfused
- Follow-up
- Within two days of decannulation
Methodological detailsobservational, inverse propensity of treatment weighting, two centres
- Observational
- Inverse propensity of treatment weighting
- Two centres
Main finding
As reported in the abstract
Average treatment effect
−0.31 units
95% CI −0.40 to −0.22
By group
Observational data: associations, not effects.
Further findings
| Outcome | Difference (g/L) (95% CI) | |
|---|---|---|
| Hb after decannulation | 5.0 (4.2–5.8) | |
| −50510Difference, g/L (linear scale) |
| Outcome | Estimate |
|---|---|
| Any PRBC transfusionBCS vs n-BCS | risk reduction 17.1% (95% CI 11.1%–22.9%) |
| Any PRBC transfusionBCS vs n-BCS | NNT 6 (95% CI 5–9) |
Original publication
The effects of blood cell salvage on transfusion requirements after decannulation from veno-venous extracorporeal membrane oxygenation: an emulated trial analysis. Crit Care. Published 5 December 2024. doi:10.
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