Impact of post-decannulation high fever on mortality in patients with severe acute respiratory distress syndrome (ARDS) treated with veno-venous extracorporeal membrane oxygenation (ECMO): a multicenter retrospective study
Authors' conclusion
Post-decannulation high fever occurs in nearly one-fourth of patients with severe ARDS treated with V-V ECMO. Its association with mortality appears to differ depending on the infection status at decannulation
Study context
- Population
- Adults with severe ARDS successfully weaned off V–V ECMO, 24 institutions in Japan, 2012–2022
- Participants
- 522 adults · 24 institutions
- Comparison
- Post-decannulation high fever vs no fever
- High-fevern = 121
- Primary endpoint
- In-hospital mortality
- Follow-up
- 90 days
Methodological detailsmulticentre, Cox proportional hazards models
- Multicentre
- Cox proportional hazards models
Primary result
As reported in the abstract
Hazard ratio
0.92
95% CI 0.55–1.56
P = 0.770
By group
High-fever vs No-fever
HR 0.92 (95% CI 0.55–1.56); P = 0.770
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| 90-day in-hospital mortality, patients with infection (subgroup) | 0.33 (0.12–0.89) | P = 0.045 | |
| 90-day in-hospital mortality, patients without infection (subgroup) | 2.25 (1.23–4.11) | P = 0.011 | |
| 0.10.31310Hazard ratio (log scale) |
Incidence of post-decannulation high fever · within 3 days after decannulation
- Developed high fever
- 121 (23.2%)
Original publication
Impact of post-decannulation high fever on mortality in patients with severe ARDS treated with veno-venous ECMO: a multicenter retrospective study. J Intensive Care. Published 11 February 2026. doi:10.
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