Effects of combined dexamethasone and dexmedetomidine as adjuncts to peripheral nerve blocks: a systematic review with meta-analysis and trial sequential analysis
Authors' conclusion
Combined dexamethasone and dexmedetomidine likely increased the duration of analgesia when compared with placebo and dexmedetomidine. The combination likely provided a similar duration of analgesia as dexamethasone.
Study context
- Population
- Adults undergoing surgery with a peripheral nerve block9 RCTs · 14 comparisons
- Comparison
- Combined dexamethasone and dexmedetomidine vs placebo or other adjuncts to peripheral nerve blocks
- Placebon = 173reference
- Dexamethasonen = 569reference
- Dexmedetomidinen = 281reference
- Outcome
- Duration of analgesia
Methodological detailstrial sequential analysis, risk of bias-2, GRADE assessment
- Trial sequential analysis
- Risk of bias-2
- GRADE assessment
Pooled result
As reported in the abstract
Mean difference, min (95% CI)
Combination vs Placebo3 RCTs, 173 participants
460(249–671)
Combination vs Dexmedetomidine4 RCTs, 281 participants
388(211–565)
Combination vs Dexamethasone7 RCTs, 569 participants; likely similar
50(−140 to 239)
Original publication
Effects of combined dexamethasone and dexmedetomidine as adjuncts to peripheral nerve blocks: a systematic review with meta-analysis and trial sequential analysis. Reg Anesth Pain Med. Published 22 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →