Effects of Dexmedetomidine Combined With Lidocaine Topical Administration on Cough Reflex During Extubation in Thyroidectomy Patients: A Randomized Clinical Trial
Authors' conclusion
The combination of dexmedetomidine and lidocaine laryngopharynx spray effectively suppresses the cough reflex during extubation, reduces postoperative sore throat, and stabilizes hemodynamics in female patients undergoing thyroid surgery.
Study context
- Population
- Female patients aged 18 to 65 years undergoing elective thyroidectomy under GA
- Participants
- 180 patients
- Comparison
- Dex-Lido vs Lido vs Control
- Dex-Lidon = 60
- Lidon = 60
- Controln = 60reference
- Primary endpoint
- Incidence of cough reflex at extubation
Primary result
As reported in the abstract
Odds ratio (95% CI)P value
Dex-Lido vs Control
0.13(0.06–0.29)
P < 0.001Lido vs Control
0.38(0.18–0.79)
P = 0.010Dex-Lido vs Lido
0.35(0.16–0.76)
P = 0.007Secondary outcomes
| Outcome | Dex-Lido | Control | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Cough severityDex-Lido vs Control | 8/60 | 26/60 | 0.20 (0.08–0.50) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Effects of Dexmedetomidine Combined With Lidocaine Topical Administration on Cough Reflex During Extubation in Thyroidectomy Patients: A Randomized Clinical Trial. Anesth Analg. Published 8 May 2025. doi:10.
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