Topical Lidocaine During Airway Manipulation in Pediatric Anesthesia: A Systematic Review and Meta‐Analysis
Authors' conclusion
Our findings suggest that topical lidocaine may reduce the incidence of undesirable airway reflexes such as laryngospasm, desaturation, and sore throat in children undergoing airway management.
Study context
- Population
- Children undergoing airway management in anaesthesia
- Participants
- 1,937 children · 14 RCTs
- Comparison
- Topical lidocaine vs placebo, no intervention, or IV lidocaine
- Topical lidocainen = 917
- Outcome
- Respiratory adverse events
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Topical lidocaine vs ControlOdds ratio (95% CI)P value
Laryngospasm
0.50(0.27–0.95)
P = 0.033Desaturation
0.49(0.25–0.98)
P = 0.043Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Sore throat | 0.31 (0.16–0.58) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Topical Lidocaine During Airway Manipulation in Pediatric Anesthesia: A Systematic Review and Meta‐Analysis. Paediatr Anaesth. Published 11 November 2025. doi:10.
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