The effects of higher versus lower protein delivery in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
Pooled result · Overall mortalityResult — go to the resultRelative risk 0.99 95% CI 0.88–1.11Authors' conclusion
Higher, compared with lower protein delivery, does not appear to affect clinical outcomes in general critically ill patients but may increase mortality rates in patients with AKI.
Study context
- Population
- Adult critically ill patients
- Participants
- 3,303 patients · 23 randomized controlled trials (RCTs)
- Comparison
- Higher vs lower protein delivery with similar energy delivery
- Outcome
- Overall mortality
Methodological detailsrandom-effect meta-analyses, trial sequential analysis
- Random-effect meta-analyses
- Trial sequential analysis
Pooled result
As reported in the abstract
Relative risk
0.99
95% CI 0.88–1.11
Higher protein vs Lower protein
RR 0.99 (95% CI 0.88–1.11)
Further pooled results
| Outcome | SMD (95% CI) | |
|---|---|---|
| Self-reported QoL physical function, with combined early physical rehabilitation (subgroup) · day-90I2 = 30%; 2 small studies; trend | 0.40 (- 0.04 to 0.84) | |
| −0.500.51Difference (linear scale) |
| Outcome | RR (95% CI) | |
|---|---|---|
| Mortality, AKI (subgroup)I2 = 0%; 3 studies; confirmed by TSA, high certainty | 1.42 (1.11–1.82) | |
| 0.512Relative risk (log scale) |
- Mortality, acute kidney injury (AKI) (subgroup) — NNH
- 7
Safety
| Outcome | MD (mmol/L) (95% CI) | |
|---|---|---|
| Serum ureaI2 = 0%; 7 studies | 2.31 (1.64–2.97) | |
| −2024Difference, mmol/L (linear scale) |
Original publication
The effects of higher versus lower protein delivery in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. Crit Care. Published 6 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →