Efficacy of permissive underfeeding for critically ill patients: an updated systematic review and trial sequential meta-analysis
Authors' conclusion
Permissive underfeeding may reduce ICU mortality in critically ill patients and help to shorten mechanical ventilation duration, but the overall mortality is not improved.
Study context
- Population
- Critically ill patients admitted to the intensive care unit (ICU)
- Participants
- 11,444 patients · 23 randomized controlled trials (RCTs)
- Comparison
- Permissive underfeeding vs control
- Outcome
- Overall mortality
Methodological detailsupdated review
- Updated review
Pooled result
As reported in the abstract
- No significant difference in overall mortality
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| ICU mortalityI2 = 0% · trial sequential analysis performed | 0.90 (0.81–0.99) | P = 0.02 | |
| 0.512Relative risk (log scale) |
Hospital mortality, hospital LOS and overall infection
- No significant differences
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Gastrointestinal adverse eventsI2 = 56% | 0.79 (0.69–0.90) | P = 0.0003 | |
| 0.512Relative risk (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Efficacy of permissive underfeeding for critically ill patients: an updated systematic review and trial sequential meta-analysis. J Intensive Care. Published 23 January 2024. doi:10.
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